Production of the antifungal biopesticide physcion through the combination of microbial fermentation and chemical post-treatment

Abstract Physcion is an anthraquinone compound observed dominantly in medicinal herbs. This possesses a variety of pharmaceutically important activities and has been developed to be widely used antifungal biopesticide. Herein, we report on the effective preparation 3R -torosachrysone ( 4 ), tetrahydroanthracene precursor physcion, Aspergillus oryzae NSAR1 by heterologous expression related genes mined from phlegmacins-producing ascomycete Talaromyces sp. F08Z-0631. Conditions for converting into physcion were studied optimized, leading development concise approach extracting high-purity alkali-treated fermentation broth -producing A. strain. Graphical